产品介绍
产品与服务首页 > 产品与服务 > 人蛋白芯片
人蛋白质：20,240种
一张芯片上的点阵数目：1
点样环境：温度4-8℃，湿度30%~40%
芯片基片：PATH，尺寸为75*25 mm
点直径：~60微米
样品重复：每个样品重复两个点
点体积：0.5~1 nl/点
芯片点制后处理：4℃过夜固定后-80℃长期保存
人蛋白质组芯片-蛋白list下载：http://www.cdi-lab.com/Resources.html
1. 药物作用靶标发现及药物作用机理研究
2. 血清标识物和新免疫原的发现
3. 蛋白质-蛋白质相互作用研究
4. 蛋白质翻译后修饰研究
5. 非编码RNA作用机制研究
6. 蛋白质与DNA相互作用研究
7. 抗体特异性筛选
8. 酶底物研究
参考文献
1. McClymont SA et al. (2018) Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons. Am J Hum Genet 103(6):874-89. [PubMed] [Full Text]
2. Feng Y et al. (2018) High-Throughput Chip Assay for Investigating Escherichia coli Interaction with the Blood-Brain Barrier Using Microbial and Human Proteome Microarrays (Dual-Microarray Technology). Anal Chem 90(18):10958-10966. [PubMed]
3. Song G et al. (2018) Proteome-wide tyrosine phosphorylation analysis reveals dysregulated signaling pathways in ovarian tumors. Mol Cell Proteomics mcp.RA118.000851 [PubMed] [Full Text]
4. Uzoma I et al. (2018) Global Identification of Small Ubiquitin-related Modifier (SUMO) Substrates Reveals Crosstalkbetween SUMOylation and Phosphorylation Promotes Cell Migration. Mol Cell Proteomics 17(5):871-888. [PubMed] [Full Text]
5. Lastwika KJ et al. (2018) Tumor-Derived Autoantibodies Identify Malignant Pulmonary Nodules. Am J Respir Crit Care Med Nov 13. doi: 10.1164/rccm.201804-0628OC. [Epub ahead of print][Abstract]
6. Gowans MF et al. (2018) Baseline antibody profiles predict toxicity in melanoma patients treated with immune checkpoint inhibitors. J Transl Med16:82. [Full Text]
7. Venkataraman A et al. (2018) A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors. Nature Methodsdoi:10.1038/nmeth.4632. [Full Text]
8. Chung JM et al. (2018) Identification of the Thioredoxin-Like 2 Autoantibody as a Specific Biomarker for Triple-Negative Breast Cancer. J Breast Cancer 21:87-90. [Full Text]
9. Bremmer HD et al. (2018) ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease. Sci Rep 8:4852. [PubMed] [Full Text]
10. Coll JM (2018) Herpesvirus Infection Induces both Specific and Heterologous Antiviral Antibodies in Carp. Front Immunol 9:39.
[PubMed] [Full Text]
11. Guo G et al. (2018) The cytomegalovirus protein US31 induces inflammation through mono-macrophages in systemic lupus erythematosus by promoting NF-κB2 activation. Cell Death Disease 9:104. doi: 10.1038/s41419-017-0122-4. [PubMed] [Full Text]
12. Pan J et al. (2017) Identification of Serological Biomarkers for Early Diagnosisof Lung Cancer Using a Protein Array-Based Approach. Mol Cell Proteomics 16:2069-2078. [PubMed] [Full Text]
13. Huang Y and Zhu H (2017) Protein Array-based Approaches for Biomarker Discovery in Cancer. Genomics Proteomics Bioinformatics 15:73-81. [PubMed] [Full Text]
14. Bigley V et al. (2017) Biallelic interferon regulatory factor 8 mutation: A complex immunodeficiency syndrome with dendritic cell deficiency, monocytopenia, and immune dysregulation. J Allergy Clin Immunol doi.org/10.1016/j.jaci.2017.08.044 [PubMed] [Full Text]
15. Sterner E et al. (2017) Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies. Cell Rep 20:1681-1691. [PubMed] [Full Text]
16. Washburn N et al. (2017) High-resolution physicochemical characterization of different intravenous immunoglobulin products. PLoS One12(7):e0181251. doi: 10.1371/journal.pone.0181251. [PubMed] [Full Text]
17. Xu Z et al. (2017) Systematic identification of the protein substrates of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T1/T2/T3 using a human proteome microarray. Proteomics 17(11):doi: 10.1002/pmic.201600485 [PubMed]
18. Yang Z et al. (2017) A Human Proteome Array Approach to Identifying Key Host Proteins Targeted by Toxoplasma Kinase ROP18. Mol Cell Proteomics 16(3):469-484 [Full Text]
19. Gupta S et al. (2017) Evaluation of autoantibody signatures in meningioma patients using human proteome arrays. Oncotarget Apr 10. doi: 10.18632/oncotarget.16997. [PubMed] [Full Text]
20. Chung BK et al. (2017) Phenotyping and auto-antibody production by liver-infiltrating B cells in primary sclerosing cholangitis and primary biliary cholangitis. J Autoimmun 77:45-54. [PubMed]
21. Cheng X et al. (2017) Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor. Oncotarget 8(2):2681-2693. [Full Text]
22. Gupta S et al. (2017) Serum Profiling for Identification of Autoantibody Signatures in Diseases Using Protein Microarrays. Methods Mol Biol1619:303-315. [PubMed]
23. Cox E et al. (2017) Global Analysis of SUMO-Binding Proteins Identifies SUMOylation as a Key Regulator of the INO80 Chromatin Remodeling Complex. Mol Cell Proteomics 16, Mar 2. doi: 10.1074/mcp.M116.063719. [Full Text]
24. Barry G et al. (2017) The long non-coding RNA NEAT1 is responsive to neuronal activity and is associated with hyperexcitability states. Nature Scientific Reports 7, Article number: 40127 doi:10.1038/srep40127 [Full Text]
25. Shi L et al. (2016) Application of high-throughput protein array in clinical screening for tumor markers. Int J Clin Exp Med 9:8529-8535.
[Full Text]
26. Iyama S et al. (2016) Drebrin: A new oncofetal biomarker associated with prognosis of lung adenocarcinoma. Lung Cancer 102:74-81. [PubMed]
27. Blackshaw S et al. (2016) The NIH Protein Capture Reagents Program (PCRP): a standardized protein affinity reagent toolbox. Nat Methods 13:805-806. [PubMed]
28. Cheng X et al. (2016) Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor. Oncotarget DOI: 10.18632/oncotarget.13153. [PubMed]
29. Hu CJ et al. (2016) Identification of Novel Biomarkers for Behcet Disease Diagnosis Using HuProt Array Approach. Mol Cell Proteomics 2016 Oct 24. pii: mcp.M. 116.061002. [PubMed]
30. Wang Y et al. (2016) A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1. Science 354 2016 Oct 7 DOI: 10.1126/science.aad6872. [Link]
31. Ogishi M et al. (2016) Delineation of autoantibody repertoire through differential proteogenomics in hepatitis C virus-induced cryoglobulinemia. Sci Rep 6:29532. [PubMed, Full Text]
32. Li H et al. (2016) Penetrance of Congenital Heart Disease in a Mouse Model of Down Syndrome Depends on a Trisomic Potentiator of a Disomic Modifier. Genetics2016 Mar 30. pii: genetics.116.188045. [PubMed]
33. Yang L et al. (2016) Identification of serum biomarkers for gastric cancer diagnosis using a human proteome microarray. Mol Cell Proteomics 15(2):614-23. doi: 10.1074/mcp.M115.051250. Epub 2015 Nov 23 [PubMed]
34. Syed P et al.(2016) Autoantibody Profiling of Glioma Serum Samples to Identify Biomarkers Using Human Proteome Arrays Sci Rep2015 Sep 15;5:13895. doi: 10.1038/srep13895. [PubMed]
35. Dart AE et al. (2015) PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. J Cell Biol 211:863-879.
[PubMed] [Full Text]
36. Ainscough JS et al. (2015) Interleukin-1β Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin. J Biol Chem 290:31151-61. [PubMed] [Full Text]
37. Zhang K et al. (2015) The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature 525:56-61. [PubMed] [Full Text]
38. Zhang HN et al. (2015) Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic. Proc Natl Acad Sci USA 112(49):15084-9. [PubMed]
39. Hu J et al. (2015) Systematic Prediction of Scaffold Proteins Reveals New Design Principles in Scaffold-Mediated Signal Transduction. Comput Biol 112(9): e1004508. [PubMed]
40. Cox E et al. (2015) Identification of SUMO E3 ligase-specific substrates using the HuProt human proteome microarray. Methods Mol Biol 1295:455-63. [PubMed]
41. Hu C et al. (2015) Autoantibody Profiling on Human Proteome Microarray for Biomarker Discovery in Cerebrospinal Fluid and Sera of Neuropsychiatric Lupus. PLoS One 10:e0126643. [PubMed] [Full text]
42. Liu S et al. (2014) Characterization of monoclonal antibody's binding kinetics using oblique-incidence reflectivity difference approach. MAbs 7:110-119. [PubMed] [Full text]
43. Jung JG et al. (2014) Notch3 interactome analysis identified WWP2 as a negative regulator of Notch3 signaling in ovarian cancer. PLos Genet 10:e1004751. [PubMed]
44. Fan Q et al. (2014) Identification of proteins that interact with alpha A-crystallin using a human proteome microarray. Mol Vis 20:117–124. [PubMed]
45. Deng RP et al. (2014) Global Identification of O-GlcNAc Transferase (OGT) Interactors by a Human Proteome Microarray and the Construction of an OGT Interactome. Proteomics 14(9): 1020-30. doi: 10.1002/pmic.201300144. Epub 2014 Mar 25.0. [PubMed]
46. Ma TM et al. (2014) Serine Racemase Regulated by Binding to Stargazin and PSD-95: Potential NMDA-AMPA Glutamate Neurotransmission Cross-talk. J Biol Chem pii: jbc. M114.571604 [Epub ahead of print]; First Published on August 27, 2014. [PubMed]
47. Barry G et al. (2013) The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing. Molec Psychiatry Apr 30. doi: 10.1038/mp.2013.45. ePub ahead of print. [PubMed]
48. Lee YI et al. (2013) Protein microarray characterization of the S-nitrosoproteome. Mol Cell Proteomics 13:63-72. [PubMed]
49. Chen Y et al. (2013) Bcl2-associated Athanogene 3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity. Mol Cell Proteomics 12(10):2804-19. [PubMed]
50. Donnelly CJ et al. (2013) RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention. Neuron 80(2):415-28. [PubMed]
51. Fan B et al. (2013) A human proteome microarray identifies that the heterogeneous nuclear ribonucleoprotein K (hnRNP K) recognizes the 5’ terminal sequence of the hepatitis C virus RNA. Mol Cell Proteomics 13(1):84-92. [PubMed]
52. Tarrant MK et al. (2012) Regulation of CK2 by phosphorylation and O-GlcNAcylation revealed by semisynthesis. Nat Chem Biol 8(3):262-9. [PubMed]
53. Jeong JS et al. (2012) Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics 11(6):O111.016253. [PubMed]
54. Huang Y et al. (2012). Global tumor protein p53/p63 interactome: making a case for cisplatin chemoresistance. Cell Cycle 11(12):2367-79. [PubMed]
55. Hu CJ et al. (2012). Identification of new autoantigens for primary biliary cirrhosis using human proteome microarrays. Mol Cell Proteomics 11(9):669-80. [PubMed]