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We have developed 8 microarrays based on the tuberculosis proteome library for functional studies:

Name

Description

Proteins of   this type in  MTB

Proteins of this type on  chip

Coverage

Reference

MTB secreted proteins

Secreted proteins may be associated with infection, virulence or immune stimulation.

257

231

90%

Malen et al., Proteomics, 2007

MTB Serine/threonine protein kinases

Kinases are enzymes that transfer phosphate groups from high-energy donor molecules, such as ATP, to specific substrates, a process referred to as phosphorylation.

11

11

100%

Cole et al., Nature, 1998

MTB transcription factors

A transcription factor is a protein that binds to the 5'-end of a DNA sequence, thereby controlling the rate of transcription of genetic information from DNA to mRNA.

185

181

98%

Cole et al., Nature, 1998

MTB lipid metabolism related proteins

Proteins involved in lipid metabolism.

272

243

89%

Cole et al., Nature, 1998

MTB metabolic pathway proteins

Proteins involved in metabolism (other than lipid metabolism), e.g. sugar, ketone, or acid metabolism.

290

269

93%

Cole et al., Nature, 1998

MTB drug resistance related proteins

MTB proteins which may be involved in natural drug resistance.

85

76

89%

Zhang et al., Nature Genetics, 2013

MTB PE/PPE family proteins

Two major protein families containing proteins with sequences similar to PE or PPE proteins. May be involved in immune responses etc.

168

122

73%

Cole et al., Nature, 1998

MTB virulence factor proteins

Proteins involved in MTB toxicity.

205

184

90%

Forrellad et al., Virulence, 2013

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